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2003•PubMedOpen access

A quantitative analysis of the expression of alpha-smooth muscle actin in mesangioproliferative (GnMes) glomerulonephritis.

Edyta Nieruchalska, Rafał Strzelczyk, Aldona Woźniak, Jakub Żurawski, Elżbieta Kaczmarek, Wieslawa Salwa-Zurawska

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Abstract

The aim of the study was to quantitatively assess the expression of alpha-SMA in the renal interstitium in GnMes cases. Two image analysis approaches (in grey scale and in spatial colour images) were used to determine correctly the presence of the reaction. In spatial evaluation, the mean area fraction of a-SMA in the renal interstitium was 3.63% +/- 1.29%, while the results obtained from traditional quantitative method based on grey scale images were biased and too low.

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What this paper is about

The aim of the study was to quantitatively assess the expression of alpha-SMA in the renal interstitium in GnMes cases. Two image analysis approaches (in grey scale and in spatial colour images) were used to determine correctly the presence of the reaction. In spatial evaluation, the mean area fraction of a-SMA in the renal interstitium was 3.63% +/- 1.29%, while the results obtained from traditional quantitative method based on grey scale images were biased and too low.

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Available abstract

The aim of the study was to quantitatively assess the expression of alpha-SMA in the renal interstitium in GnMes cases. Two image analysis approaches (in grey scale and in spatial colour images) were used to determine correctly the presence of the reaction. In spatial evaluation, the mean area fraction of a-SMA in the renal interstitium was 3.63% +/- 1.29%, while the results obtained from traditional quantitative method based on grey scale images were biased and too low.

Key concepts: Grey scale, SMA*, Alpha (finance), Scale (ratio), Anatomy, Pathology, Medicine, Mathematics

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A quantitative analysis of the expression of alpha-smooth muscle actin in mesangioproliferative (GnMes) glomerulonephritis. — Research Paper | ScholarLens