1957•The Medical Journal of AustraliaRequires access
ACTIVE IMMUNIZATION AGAINST TETANUS
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Abstract
ACTIVE immunization against tetanus has aroused a great deal of in-terest among clinicians and public health workers because of its possible use as a preventive measure of general applicability. The antitoxin titer pro-duced by the injection of tetanus toxoid, and the influence exerted upon this titer by such factors as dosage, time interval between injections, associated antigens and " repeat " or stimulating injection of toxoid, have been the subject of careful investigation.1"32 We now wish to add our findings on the comparative value of various antigenic preparations. Tetanus toxoid (plain) (No. 5969), tetanus toxoid (plain) to which 0.4 per cent alum was added (No. 5969-5) and alum precipitated tetanus toxoid (refined) (No. 8387-3) were used for active immunization of 32 healthy individuals, 14 to 28 years of age. Twelve persons (group A) f were immunized by means of three 1.0 c.c. injections of tetanus toxoid plain (No. 5969). The period between injec-tions was varied in order to determine the interval of time that will give the