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2009•Asian Journal of Research in ChemistryRequires access

UV Spectrophotometric Method Development for the Determination of Domperidone in Tablet Formulation

Kailash Nath Kaushik, Saurabh Kumar Banerjee

Open publisher page 2 citations

Abstract

A simple, accurate, precise and reproducible method for the estimation of domperidone (DOM) in tablet dosage form was developed utilizing concept of UV spectrophotometry. Methanol was used as the solvent for domperidone. The UV spectrum of domperidone in methanol showed I max at 287.5 nm and Beer-Lambert law was obeyed in the concentration range of 6–36 μg/ml. Wavelength selected for estimation of domperidone was 287.5 nm. The result of analysis has been validated statistically. The recovery studies range from 99.5 to 100.1% confirmed the accuracy of the proposed methods.

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What this paper is about

A simple, accurate, precise and reproducible method for the estimation of domperidone (DOM) in tablet dosage form was developed utilizing concept of UV spectrophotometry. Methanol was used as the solvent for domperidone. The UV spectrum of domperidone in methanol showed I max at 287.5 nm and Beer-Lambert law was obeyed in the concentration range of 6–36 μg/ml. Wavelength selected for estimation of domperidone was 287.5 nm. The result of analysis has been validated statistically. The recovery studies range from 99.5 to 100.1% confirmed the accuracy of the proposed methods.

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Available abstract

A simple, accurate, precise and reproducible method for the estimation of domperidone (DOM) in tablet dosage form was developed utilizing concept of UV spectrophotometry. Methanol was used as the solvent for domperidone. The UV spectrum of domperidone in methanol showed I max at 287.5 nm and Beer-Lambert law was obeyed in the concentration range of 6–36 μg/ml. Wavelength selected for estimation of domperidone was 287.5 nm. The result of analysis has been validated statistically. The recovery studies range from 99.5 to 100.1% confirmed the accuracy of the proposed methods.

Key concepts: Domperidone, Beer–Lambert law, Methanol, Chromatography, Dosage form, Spectrophotometry, Solvent, Materials science

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