2013•Natural Product CommunicationsOpen access

Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora

Deepali Katoch, Dharmesh Kumar, Upendra Sharma, Neeraj Kumar, Yogendra Padwad, Brij Lal, Bikram Singh

Abstract

Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.

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Key concepts: Lycorine, Amaryllidaceae, Alkaloid, Betaine, Chinese hamster ovary cell, Biology, Traditional medicine, Pharmacognosy