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Gamma irradiation on rat whole blood cholinesterase

Martin W. Williams

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Abstract

Rat whole blood cholinesterase levels were followed electrometrically for 10 days following whole-body irradiation with 300 and 600 r gamma rays from a Co60 source. Cholinesterase activity was significantly depressed in both groups after the 3rd day, reaching its lowest observed levels on the 10th day. The toxicity of acetylcholine bromide was significantly greater to mice 9 days after 300 r of whole-body gamma irradiation than in nonirradiated controls as indicated by the intraperitoneal ld50 which was 294 mg/kg prior to, and 235 mg/kg after, irradiation.

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Rat whole blood cholinesterase levels were followed electrometrically for 10 days following whole-body irradiation with 300 and 600 r gamma rays from a Co60 source. Cholinesterase activity was significantly depressed in both groups after the 3rd day, reaching its lowest observed levels on the 10th day. The toxicity of acetylcholine bromide was significantly greater to mice 9 days after 300 r of whole-body gamma irradiation than in nonirradiated controls as indicated by the intraperitoneal ld50 which was 294 mg/kg prior to, and 235 mg/kg after, irradiation.

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Available abstract

Rat whole blood cholinesterase levels were followed electrometrically for 10 days following whole-body irradiation with 300 and 600 r gamma rays from a Co60 source. Cholinesterase activity was significantly depressed in both groups after the 3rd day, reaching its lowest observed levels on the 10th day. The toxicity of acetylcholine bromide was significantly greater to mice 9 days after 300 r of whole-body gamma irradiation than in nonirradiated controls as indicated by the intraperitoneal ld50 which was 294 mg/kg prior to, and 235 mg/kg after, irradiation.

Key concepts: Cholinesterase, Whole body irradiation, Irradiation, Whole blood, Chemistry, Toxicity, Gamma irradiation, Acetylcholine

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