1972•Unpublished venueOpen access
PATHOLOGIC EFFECTS OF CHRONIC $sup 90$Sr INGESTION IN MINIATURE SWINE.
Battelle Pacific Northwest Labs., Richland, Wash. (USA), H. Ragan, P. Hackett, B. McClanahan, William James Clarke
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Abstract
A s -*-mi ' Over 700 female miniature swine, extending through #$E:g48-, three generations, have been ex osed to daily , Z W Sgl;!:' I ; 3 8 e s 8 2 1 feedings of from 1 to 3100 uCi !oS~.In addition, 1 2 e ~ 1 3 cf I there were 200 untreated, female, littermate controls.ij$?#jjisrsz r,l$-".tl"Body burdens of 90Sr reached approximately 7.5 and S f P a a ~g @ I 10 times the daily intake i n the original and F1- 25 pCi/day (5000-20,000 rads accumul ated skeletal doses), there occurred a progressive decrease in circulating leukocytes and platelets, and a precipitous, terminal f a l l , i n erythrocytes, w i t h many of these animals dying of hemorrhagic diatheses.A second syndrome, observed particul arly i n animal s a t the 125 and 625 uCi/day levels, was a broad spectrum of weloproliferation ranging from myeloid metaplasia t o frank blast cell leukem'ia., .. I *
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