2015•Journal of Cancer Research and TherapeuticsOpen access

Gliosarcoma with leiomyomatous differentiation: A case report with an emphasis on histogenesis

Saumya Shukla, Namrata Punit Awasthi, Pradyumn Singh, Nuzhat Husain, Bal Krishna Ojha

Abstract

Gliosarcoma is an uncommon high-grade tumor which constitutes about 2% of all glioblastomas. These tumors have the histological hallmark of a biphasic pattern of high-grade glial and sarcomatous components. The histogenesis of these tumors is controversial. We report a case of primary gliosarcoma in an adult male with leiomyomatous differentiation and discuss the histogenesis as it appears in our case. Primary gliosarcomas of the brain are clinically challenging with a poor clinical outcome.

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Key concepts: Histogenesis, Gliosarcoma, Pathology, Biology, Medicine, Glioblastoma, Immunohistochemistry, Cancer research