Direct Thrombin Inhibitors

Anticoagulation can be achieved by inhibition of the various coagulation factors. Non-VKA oral anticoagulant (NOAC) development has focused on the synthesis of selective inhibitors of coagulation factors, preferably acting independently of cofactors. The NOACs act on a number of targets in the coagulation cascade, but two of its key factors, Xa and IIa (thrombin), are the major therapeutic targets. As they are involved in the final steps of the coagulation cascade, their inhibition allows blocking of both intrinsic and extrinsic coagulation pathways. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.