Efecto hipotensor de latanoprost, travoprost y bimatoprost en pacientes con hipertensión ocular y glaucoma primario de ángulo abierto

SUMMARY Purposes: To compare the ocular hypontensor effect of latanoprost, travoprost and bimatoprost in patients with ocular hypertension (OH) and open angle primary glaucoma (OAPG). To evaluate the intraocular tension variations during the day and the main adverses effects of these drugs. Patients and methods: A experimental, longitudinal, prospective, comparative and blind evaluator study was done. Three patients groups were organized, with latanoprost (0.005%), travoprost (0.004%) and bimatoprost (0.03%) application respectively. The intraocular pressure (IOP) and the adverses effects of the drugs were evaluated the day 0 (base), week 1, 4, 8 and 12 of treatment. Results: Eigthteen patients were studied (36 eyes). In all of them the intraocular tension was more of 30% less in comparison with the initial measure and had a significative level (p=0.03). The more common adverse effect was the conjuntival hiperemy. There were not important intraocular pressure variations during the day. Conclusions: There was average IOP significative diminution respect to the base in the three study groups. Bimatoprost diminished the IOP 40.5% in comparison with 34.8% y 36.7% for latanoprost and travoprost respectively.