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2015•OnLine Journal of Biological SciencesOpen access

Hypermethylation and Hypomethylation of DNA: Implication for Diagnosis and Prognosis of Prostate Cancer

Ľuboš Danišovič, Stanislav Žiaran

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Abstract

Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.

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Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.

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Available abstract

Prostate cancer belongs to the most common cancers and it is the second leading cause of cancer death in men. A genetic predisposition with epigenetic changes in DNA contributes to the development of the disease. DNA hypermethylation and hypomethylation belong to the most studied epigenetic changes in prostate cancer development. Both forms may lead to chromosomal instability and transcriptional gene silencing. This article is aimed at brief review of information in respect to DNA hypermethylation and hypomethylation in the prostate cancer development. Moreover, we discuss their implication for diagnosis and prognosis of prostate cancer.

Key concepts: DNA methylation, Epigenetics, Prostate cancer, Cancer, Gene silencing, Disease, Cancer research, Biology

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