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2012•Asian Journal of Research in ChemistryRequires access

Simultaneous Estimation of Pantoprazole and Diclofenac sodium in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method

Rajesh Patel, Ravi N. Patel, Hitesh B. Patel, Vinas A. Patel, Ashok Laxmanrao Ganure, Laxmanbhai J. Patel

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Abstract

A Derivative Spectrophotometric method has been developed for simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 291 nm (λmax for Pantoprazole) and 282 nm (λmax for Diclofenac Sodium). The linearity lies between 5–25μg/ml for Pantoprazole and 10–50μg/ml for Diclofenac Sodium. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2%.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined pharmaceutical dosage form.

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What this paper is about

A Derivative Spectrophotometric method has been developed for simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 291 nm (λmax for Pantoprazole) and 282 nm (λmax for Diclofenac Sodium). The linearity lies between 5–25μg/ml for Pantoprazole and 10–50μg/ml for Diclofenac Sodium. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2%.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined pharmaceutical dosage form.

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Available abstract

A Derivative Spectrophotometric method has been developed for simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 291 nm (λmax for Pantoprazole) and 282 nm (λmax for Diclofenac Sodium). The linearity lies between 5–25μg/ml for Pantoprazole and 10–50μg/ml for Diclofenac Sodium. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2%.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined pharmaceutical dosage form.

Key concepts: Pantoprazole, Diclofenac Sodium, Dosage form, Chemistry, Chromatography, Absorbance, Diclofenac, Reproducibility

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Simultaneous Estimation of Pantoprazole and Diclofenac sodium in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method — Research Paper | ScholarLens