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Establishment and characterization of the pluripotent mouse teratocarcinoma cell line TCE.

Wobus Am, H.-J. Holzhausen, Carlos Bloch, Antje Intek, Kathrin Becker, Gerald Walter, Jiřı́ Forejt, J. Schöneich

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Abstract

Embryonal carcinoma cells, the stem cells of teratocarcinomas, are a convenient model system for the study of embryonic development and cell differentiation. We established the pluripotent teratocarcinoma cell line TCE from embryoid bodies of teratocarcinoma strain OTT6050. The feeder independent cell line was characterized with regard to karyotype, differentiation capacities, developmentally regulated gene products, such as alkaline and acid phosphatase, cell surface markers, and by intermediate filament proteins. These parameters are discussed with respect to the developmental potency of the cell line TCE.

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What this paper is about

Embryonal carcinoma cells, the stem cells of teratocarcinomas, are a convenient model system for the study of embryonic development and cell differentiation. We established the pluripotent teratocarcinoma cell line TCE from embryoid bodies of teratocarcinoma strain OTT6050. The feeder independent cell line was characterized with regard to karyotype, differentiation capacities, developmentally regulated gene products, such as alkaline and acid phosphatase, cell surface markers, and by intermediate filament proteins. These parameters are discussed with respect to the developmental potency of the cell line TCE.

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Available abstract

Embryonal carcinoma cells, the stem cells of teratocarcinomas, are a convenient model system for the study of embryonic development and cell differentiation. We established the pluripotent teratocarcinoma cell line TCE from embryoid bodies of teratocarcinoma strain OTT6050. The feeder independent cell line was characterized with regard to karyotype, differentiation capacities, developmentally regulated gene products, such as alkaline and acid phosphatase, cell surface markers, and by intermediate filament proteins. These parameters are discussed with respect to the developmental potency of the cell line TCE.

Key concepts: Teratocarcinoma, Embryoid body, Embryonic stem cell, Cell culture, Induced pluripotent stem cell, Embryonal carcinoma, Cell biology, Cellular differentiation

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