Transdermal Drug Delivery System with Formulation and Evaluation Aspects: Overview

Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. The conventional oral dosage forms has significant drawbacks of poor bioavailability due to hepatic first pass metabolism and tendency to produce major fraction of drug is transported into the systemic blood circulation, leading to a need for high or frequent dosing, which can be both cost prohibitive and inconvenient. To improve such characters transdermal drug delivery system (TDDS) was emerged which will improve the therapeutic efficacy and safety of drugs by more precise (i.e. site specific) placement within the body thereby reducing both the size and number of doses. Today number of drugs is taken orally and is found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. This article provides an overview on introduction about the transdermal drug delivery system and types of Transdermal patches, use of polymer as a transdermal drug delivery system, methods of preparation, and its physicochemical methods of evaluation and the types of transdermal systems currently available in the market to focus on the recent innovations in Transdermal Drug Delivery Systems which can be a platform for the research and development of pharmaceutical drug dosage form for Transdermal Drug Delivery.