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2015•Research in PharmacyOpen access

Benzo[a]pyrene induced liver and kidney cancer in swiss albino mice

S.Asha and D.Girija

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Abstract

This study has been undertaken to find out the carcinogenic effect of benzo[a]pyrene induced oxidative damage in liver and kidney of swiss albino mice. Adult male swiss albino mice were exposed to benzo[a]pyrene (dissolved in corn oil) twice a week for a period of 60 days and 90 days (50mg /kg body weight). Level of lipid peroxidation and activities of enzymic antioxidants and non-enzymic antioxidants were studied. The results indicates that there is a marked elevation in lipid peroxidation of both target organs (livers and kidney), with a elevated level of GPx in kidney and deminished level of GPx in liver. The results also showed a decreased activities of SOD, CAT and reduced glutathione in liver and kidney. All these study concludes that benzo[a]pyrene acts as a carcinogenic agent in liver and kidney of swiss albino mice.

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What this paper is about

This study has been undertaken to find out the carcinogenic effect of benzo[a]pyrene induced oxidative damage in liver and kidney of swiss albino mice. Adult male swiss albino mice were exposed to benzo[a]pyrene (dissolved in corn oil) twice a week for a period of 60 days and 90 days (50mg /kg body weight). Level of lipid peroxidation and activities of enzymic antioxidants and non-enzymic antioxidants were studied. The results indicates that there is a marked elevation in lipid peroxidation of both target organs (livers and kidney), with a elevated level of GPx in kidney and deminished level of GPx in liver. The results also showed a decreased activities of SOD, CAT and reduced glutathione in liver and kidney. All these study concludes that benzo[a]pyrene acts as a carcinogenic agent in liver and kidney of swiss albino mice.

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Available abstract

This study has been undertaken to find out the carcinogenic effect of benzo[a]pyrene induced oxidative damage in liver and kidney of swiss albino mice. Adult male swiss albino mice were exposed to benzo[a]pyrene (dissolved in corn oil) twice a week for a period of 60 days and 90 days (50mg /kg body weight). Level of lipid peroxidation and activities of enzymic antioxidants and non-enzymic antioxidants were studied. The results indicates that there is a marked elevation in lipid peroxidation of both target organs (livers and kidney), with a elevated level of GPx in kidney and deminished level of GPx in liver. The results also showed a decreased activities of SOD, CAT and reduced glutathione in liver and kidney. All these study concludes that benzo[a]pyrene acts as a carcinogenic agent in liver and kidney of swiss albino mice.

Key concepts: Lipid peroxidation, Kidney, Carcinogen, Pyrene, Benzo(a)pyrene, Glutathione, Chemistry, Corn oil

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