HM Goodman, GP Frick, S Souza
Abstract
Unlike other mammals, primates can respond to growth hormone (GH) only of primate origin. This species specificity results from the incompatibility of the positively charged arginine found uniquely in primate GH receptors with histidine in the GH molecules in all nonprimates in place of the aspartate found in primate GHs.
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Unlike other mammals, primates can respond to growth hormone (GH) only of primate origin. This species specificity results from the incompatibility of the positively charged arginine found uniquely in primate GH receptors with histidine in the GH molecules in all nonprimates in place of the aspartate found in primate GHs.
Key concepts: Primate, Receptor, Biology, Nonhuman primate, Growth hormone, Arginine, Hormone, Hormone receptor