1958•American Journal of Physiology-Legacy ContentRequires access

Antagonistic Effects of Acetylcholine and Nicotine on Isolated Frog Hearts

Chintamani Pathak

Abstract

A study of the relationship between the actions of acetylcholine and nicotine on frog hearts indicates that both the excitatory and inhibitory effects of acetylcholine are antagonised by nicotine. Hearts stopped by acetylcholine and also spontaneously stopped hearts were restarted by nicotine. It has been suggested that exogenously administered acetylcholine and nicotine act through same receptors in a competitive manner.

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Key concepts: Nicotine, Acetylcholine, Acetylcholine receptor, Excitatory postsynaptic potential, Inhibitory postsynaptic potential, Chemistry, Pharmacology, Nicotinic agonist