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Calculation Of Biological Dose For Treatment Of Carcinoma Of Esophagus Using External Irradiation And High Dose Rate Intraluminal Irradiation

Ranjan Sur, Pritam Singh Negi, Deepinder Singh, Suresh C Sharma, Brahm D. Gupta

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Abstract

A combination of moderate doses of external beam irradiation and intraluminal irradiation has been found to give the best results in esophageal cancer. In advanced cases, with massive local disease the purpose of moderate doses of external beam irradiation is to shrink the local tumour so that intraluminal irradiation is possible in 2-3 weeks. We give 35 Gy / 15 fractions in 3 weeks by external beam and 12 Gy calculated at 1.0 cm from the centre of the source axis in two sessions of 6 Gy each, a week apart by HDR intraluminal irradiation. In this report, the various formulae necessary to calculate the effective biological dose by CRE. TDF and LQ models have been outlined when the combined modality is used for therapy.

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What this paper is about

A combination of moderate doses of external beam irradiation and intraluminal irradiation has been found to give the best results in esophageal cancer. In advanced cases, with massive local disease the purpose of moderate doses of external beam irradiation is to shrink the local tumour so that intraluminal irradiation is possible in 2-3 weeks. We give 35 Gy / 15 fractions in 3 weeks by external beam and 12 Gy calculated at 1.0 cm from the centre of the source axis in two sessions of 6 Gy each, a week apart by HDR intraluminal irradiation. In this report, the various formulae necessary to calculate the effective biological dose by CRE. TDF and LQ models have been outlined when the combined modality is used for therapy.

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Available abstract

A combination of moderate doses of external beam irradiation and intraluminal irradiation has been found to give the best results in esophageal cancer. In advanced cases, with massive local disease the purpose of moderate doses of external beam irradiation is to shrink the local tumour so that intraluminal irradiation is possible in 2-3 weeks. We give 35 Gy / 15 fractions in 3 weeks by external beam and 12 Gy calculated at 1.0 cm from the centre of the source axis in two sessions of 6 Gy each, a week apart by HDR intraluminal irradiation. In this report, the various formulae necessary to calculate the effective biological dose by CRE. TDF and LQ models have been outlined when the combined modality is used for therapy.

Key concepts: Irradiation, Esophagus, Dose rate, Nuclear medicine, Medicine, Radiochemistry, Chemistry, Internal medicine

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Calculation Of Biological Dose For Treatment Of Carcinoma Of Esophagus Using External Irradiation And High Dose Rate Intraluminal Irradiation — Research Paper | ScholarLens