On the ossification of the primordial cartilage

ABSTRACT A Microscopical analysis of the changes which take place in the ossification of cartilage has two questions to resolve: First, in what way does the peculiar structure of osseous substance arise from the so widely different structure of cartilage ? and, secondly, in this process, in what relation do the elements of the cartilage stand towards those of the bone? The latter question especially, since it has become known that bone may be formed without any pre-existing cartilage, has acquired redoubled interest.