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2016•Translational Cancer ResearchRequires access

Activated status of Hedgehog pathway in oral squamous cell carcinoma (OSCC): the door is still open

Ismael Riquelme, Juan Carlos Roa

Open publisher page 3 citations

Abstract

The Hedgehog (Hh) signaling pathway is essential for regulation of cell differentiation and organ formation in a concentration-dependent manner during embryonic development. Also, this pathway is important to the maintenance of adult stem cells. Studies have shown that three members of this family are present in mammals: Sonic hedgehog (SHH), Desert hedgehog (DHH) and Indian hedgehog (IHH), all of which encode secreted proteins (1).

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What this paper is about

The Hedgehog (Hh) signaling pathway is essential for regulation of cell differentiation and organ formation in a concentration-dependent manner during embryonic development. Also, this pathway is important to the maintenance of adult stem cells. Studies have shown that three members of this family are present in mammals: Sonic hedgehog (SHH), Desert hedgehog (DHH) and Indian hedgehog (IHH), all of which encode secreted proteins (1).

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The Hedgehog (Hh) signaling pathway is essential for regulation of cell differentiation and organ formation in a concentration-dependent manner during embryonic development. Also, this pathway is important to the maintenance of adult stem cells. Studies have shown that three members of this family are present in mammals: Sonic hedgehog (SHH), Desert hedgehog (DHH) and Indian hedgehog (IHH), all of which encode secreted proteins (1).

Key concepts: Hedgehog signaling pathway, Hedgehog, Sonic hedgehog, Basal cell, Biology, Embryonic stem cell, Cell biology, Cancer research

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Activated status of Hedgehog pathway in oral squamous cell carcinoma (OSCC): the door is still open — Research Paper | ScholarLens