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Levels of tissue factor pathway inhibitor in lupus patients correlate with lupus activity and endothelial damage markers.

Vanessa Roldán, Pascual Marco, Cristina Fernández, Eliseo Pascual

Open publisher page 7 citations

Abstract

Tissue factor (TF) is a low molecular weight glycoprotein considered a major regulator of coagulation.1 Tissue factor pathway inhibitor (TFPI) appears to play a primary role in regulating TF-induced coagulation, as it is a potent inhibitor of activated factor VII/TF complexes. TFPI is expressed by the endothelium under normal physiologic conditions. The plasma concentration of TFPI is low, and only small amounts circulate in plasma as full-length molecule (free-TFPI).

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What this paper is about

Tissue factor (TF) is a low molecular weight glycoprotein considered a major regulator of coagulation.1 Tissue factor pathway inhibitor (TFPI) appears to play a primary role in regulating TF-induced coagulation, as it is a potent inhibitor of activated factor VII/TF complexes. TFPI is expressed by the endothelium under normal physiologic conditions. The plasma concentration of TFPI is low, and only small amounts circulate in plasma as full-length molecule (free-TFPI).

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Tissue factor (TF) is a low molecular weight glycoprotein considered a major regulator of coagulation.1 Tissue factor pathway inhibitor (TFPI) appears to play a primary role in regulating TF-induced coagulation, as it is a potent inhibitor of activated factor VII/TF complexes. TFPI is expressed by the endothelium under normal physiologic conditions. The plasma concentration of TFPI is low, and only small amounts circulate in plasma as full-length molecule (free-TFPI).

Key concepts: Tissue factor pathway inhibitor, Tissue factor, Coagulation, Thromboplastin, Glycoprotein, Endothelium, Regulator, Systemic lupus erythematosus

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Levels of tissue factor pathway inhibitor in lupus patients correlate with lupus activity and endothelial damage markers. — Research Paper | ScholarLens