Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration

In this paper, the propagation (haracteristics of near-infrared (NIR) light in the palm tissue are analyzed,and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasiveblood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectancespectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopyare designed. Based on this system, oral glucose tolerance tests are performed to measure the bloodglucose concentrations of two young healthy volunteers. The partial least square calibration model is thenconstructed by all individual experimental data. The final result shows that correlation coefficients ofthe two experiments between the predicted blood glucose concentrations and the reference blood glucoseconcentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full crossvalidation are 0.54 and 0.52 mmol/1, respectively.