Manifestations of malignancies during the course of sarcoidosis

Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any organ in human body. Coexistance of two disorders is potential. Method of the work: Analysis were restrospective.All patients with histologically proved sarcoidosis were obtained. Patients were ambulatory or hospitaly treated in the Clinic for lung diseases and tuberculosis. Malignincies were also histologycally proved. Results: Among 1307 patients with sarcoidosis (ACCES group, ERS) only 15 patients with malignicies were obtained.Mean ages were 47.3 years, and 11 F/4 M ratio was find out.In 5 patients malignicies were the first obtained diagnosis in patients life as followed: carcinoma mammae (2 patients), carcinoma renis, fibrosarcoma and chronic laeucemia.The mean time in which sarcoidosis were manifested - 3,1 years. All patients were treated for carcinoma, till nowdays. In 11 patients, malignincies followed the sarcoidosis in mean time of 7.7 years: M. Hodgkin, adenocarcinoma ovarii, melanoma malignum, carcinoma cutis (3 female patients), adenocarcinoma intestine, carcinoma recti (2 patients), carcinoma mammae.Mean time of sarcoidosis duration were 8.3 years. All patients with sarcoidosis were mediacally treated even for relapses. In this group 3 lethal outcomes were obtained. Conclusion: Comorbidities exists even in sarcoidosis.The question is what is the cause for manifesting sarcoidosis and malignincies. Is immunodefitientia one of the potential factors in manifesting sarcoidosis and in manifesting malignincies. Another question is due to cytostatic drugs delivering during the treatment from malignincies. One of the known cytostatics which can cause granulomatous disorders is vinblastin.