The Expression of PLF in Placenta in Pregnancy-Induced Hypertension and the Relationship between the PLF and Serum VCAM-1

Summary: To study the expression of placental isoferritin (PLF) in placental tissue of pregnancy-in-duced hypertension (PIH) and the relationship between the level of expression of PLF and theamount of vascular cell adhesion molecule-1 (VCAM-1) in serum, immunohistochemical techniquewas used to detect the expression of PLF in placenta tissue in 45 PIH patients (PIH group) and 15normal pregnant women (normal group). High resolution pathological image analysis system(HPIAS-100) was employed to determine the quantity of PLF. The VCAM-1 in serum was exam-ined by enzyme linked immunoabsorbent assay (ELISA). The results showed that the levels of PLFexpressions in moderate and severe PIH patients were significantly lower than that of normal group(P＜0. 01). The serum VCAM-1 was significantly decreased in PIH group (1310±177 ρ/ng/ml)than that of normal group (609±72 ρ/ng/ml, P＜0. 01).The significant negative correlation exist-ed between the expression of PLF in placental tissue and the serum VACM-1 (r=-0. 58, P＜0. 01).It was concluded that the level of PLF expression in PIH decreases and is negatively correlated withthe amount of serum VCAM-1, indicating that these may be involved in the pathogenesis of PIH.