Clinicopathologic characteristics of Weneger's granulomatosis: A report of three cases

Weneger's granulomatosis (WG) is a rare autoimmune disease affecting a number of organs, including lungs and kidney. Although all age groups may be affected, the peak incidence occurs for individuals aged 30-50 years, with a slightly increased prevalence in males. In the current study, we present three cases of WG to describe clinical and pathological characteristics of this disease. Three patients with WG were assessed for clinical and pathological characteristics, and typical morphological findings using computerized tomography. Clinical manifestations included vasculitis, tissue necrosis, and the formation of granuloma. Following a large dose of glucocorticoid hormone treatment, the symptoms were successfully relieved in all three patients. In conclusion, the diagnosis of WG is dependent on pathological examination in combination with appropriate clinical and imaging data, and immunostaining with anti-neutrophil cytoplasmic antibody.