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1982•Infection and ImmunityOpen access

Respiratory syncytial virus infection in cyclophosphamide-treated cotton rats

Russell A. Johnson, Gregory A. Prince, Stephen C. Suffin, Robert L. Horswood, Robert M. Chanock

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Abstract

Cotton rats infected intranasally with respiratory syncytial virus and immunosuppressed with cyclophosphamide shed virus for at least 7 weeks. Dissemination of virus beyond the respiratory tract was observed. In contrast, virus was recovered from infected, non-immunosuppressed rats for only 1 week, and only from the respiratory tract.

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What this paper is about

Cotton rats infected intranasally with respiratory syncytial virus and immunosuppressed with cyclophosphamide shed virus for at least 7 weeks. Dissemination of virus beyond the respiratory tract was observed. In contrast, virus was recovered from infected, non-immunosuppressed rats for only 1 week, and only from the respiratory tract.

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OpenAlex reports 53 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Cotton rats infected intranasally with respiratory syncytial virus and immunosuppressed with cyclophosphamide shed virus for at least 7 weeks. Dissemination of virus beyond the respiratory tract was observed. In contrast, virus was recovered from infected, non-immunosuppressed rats for only 1 week, and only from the respiratory tract.

Key concepts: Respiratory tract, Virus, Biology, Respiratory system, Cyclophosphamide, Virology, Respiratory tract infections, Nasal administration

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