2012International Journal of Immunopathology and PharmacologyOpen access

Switch to Icatibant in a Patient Affected by Hereditary Angioedema with High Disease Activity: A Case Report

Davide Firinu, Maria Pina Barca, Lorenzo Serusi, M. M. Lorrai, M. M. Peralta, Paolo Emilio Manconi, S.R. Del Giacco

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Abstract

Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, following years of treatment with C1-inhibitor.

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Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, following years of treatment with C1-inhibitor.

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Available abstract

Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, following years of treatment with C1-inhibitor.

Key concepts: Icatibant, Hereditary angioedema, Medicine, Bradykinin, C1-inhibitor, B2 receptor, Angioedema, Dermatology

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