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Serum Markers of Bone Turnover in the Diagnosis of Renal Osteodystrophy

Aníbal Ferreira

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Abstract

Renal osteodystrophy (ROD) is a multifactor disorder of bone remodelling observed in patients with chronic renal failure (CRF) from very early stages (CRF stage 2) and associated with significant morbidity. The remodelling cycle in normal bone lasts from four to eight months and includes several phases: 1) An activation phase in which osteoclasts are mobilized and activated; 2) A resorption phase in which osteoclasts erode the bone surface; 3) A reversal phase that ends resorption and osteoblasts are recruited to the eroded surfaces; 4) Unmineralized matrix (osteoid) synthesised by osteoblasts; and 5) Mineralization of the osteoid tissue. Each of these steps (or several of them) are frequently compromised in uraemic patients. Serum markers of bone turnover in the diagnosis of renal osteodystrophy

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Renal osteodystrophy (ROD) is a multifactor disorder of bone remodelling observed in patients with chronic renal failure (CRF) from very early stages (CRF stage 2) and associated with significant morbidity. The remodelling cycle in normal bone lasts from four to eight months and includes several phases: 1) An activation phase in which osteoclasts are mobilized and activated; 2) A resorption phase in which osteoclasts erode the bone surface; 3) A reversal phase that ends resorption and osteoblasts are recruited to the eroded surfaces; 4) Unmineralized matrix (osteoid) synthesised by osteoblasts; and 5) Mineralization of the osteoid tissue. Each of these steps (or several of them) are frequently compromised in uraemic patients. Serum markers of bone turnover in the diagnosis of renal osteodystrophy

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Available abstract

Renal osteodystrophy (ROD) is a multifactor disorder of bone remodelling observed in patients with chronic renal failure (CRF) from very early stages (CRF stage 2) and associated with significant morbidity. The remodelling cycle in normal bone lasts from four to eight months and includes several phases: 1) An activation phase in which osteoclasts are mobilized and activated; 2) A resorption phase in which osteoclasts erode the bone surface; 3) A reversal phase that ends resorption and osteoblasts are recruited to the eroded surfaces; 4) Unmineralized matrix (osteoid) synthesised by osteoblasts; and 5) Mineralization of the osteoid tissue. Each of these steps (or several of them) are frequently compromised in uraemic patients. Serum markers of bone turnover in the diagnosis of renal osteodystrophy

Key concepts: Renal osteodystrophy, Osteoid, Bone remodeling, Bone resorption, Chronic kidney disease-mineral and bone disorder, Internal medicine, Resorption, Medicine

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Serum Markers of Bone Turnover in the Diagnosis of Renal Osteodystrophy — Research Paper | ScholarLens