1964•JNCI Journal of the National Cancer InstituteRequires access

Loss of Two Steroid 11β-Hydroxylating Components in a Rat Adrenocortical Carcinoma2

Max L. Sweat, Melvin J. Bryson

Abstract

Examination of the Snell homologously transferred rat Adrenocarcinoma 494 indicated a loss of two components (F-40 and F-80) associated with steroid 11β-hydroxylation in normal adrenal tissue. The tumor retained the mechanisms associated with 21-hydroxylation of progesterone and C-5 isomerization and C-3 oxidation of pregnenolone.

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Key concepts: Pregnenolone, Hydroxylation, Steroid, Endocrinology, Chemistry, Internal medicine, Isomerization, Biology