Prophylactic Effects of Mitomycin-C on Regression and Haze Formation in Photorefractive Keratectomy

<!--[if gte mso 9]> Normal 0 false false false MicrosoftInternetExplorer4 <![endif]--><!--[if gte mso 9]> <![endif]--> <!--[if gte mso 10]> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} <![endif]--> PURPOSE: To study the effect of prophylactic application of mitomycin-C on regression and corneal haze formation after photorefractive keratectomy (PRK) for high myopia. METHODS: Fifty-four eyes of 28 high myopic patients were enrolled in this prospective study. All eyes underwent PRK with application of 0.02% mitomycin-C for two minutes and irrigation with 15-20 ml of normal saline. Follow-up visits were scheduled for the first 7 days and 1, 3 and 6 months after surgery. Hanna grading (in the scale of 0 to 4+) was used to assess corneal haze. RESULTS: Mean spherical equivalent refraction (SE) was -7.08 ± 1.11 diopters (D), preoperatively. All eyes were examined on the first 7 days and one month after surgery; 48 eyes (88.9%) were evaluated 3 and 6 months post-surgery. Six months after surgery, all eyes had uncorrected visual acuity (UCVA) of 20/40 or better and 37 eyes (77.1 %) achieved UCVA of 20/20 or better, 45 eyes (93.7%) had SE within ±1.00D of emmetropia. One month postoperatively, 2 eyes (3.7%) had grade 0.5 haze, while at 3 and 6 months after surgery no visited eye had haze at all. There was no decrease in best corrected visual acuity after 6 months. In spatial frequencies of 6 and 12 cycle/degree, contrast sensitivity decreased immediately after PRK but increased to the preoperative values by the 6th postoperative month. CONCLUSION: Mitomycin-C can prevent the development of corneal haze when treating high myopia with PRK. In patients with insufficient corneal thickness for laser in situ keratomileusis (LASIK), mitomycin-C makes a useful adjunct to PRK to provide an alternative treatment for myopia. However, further research with longer follow-up is suggested. <!--[if gte mso 9]> Normal 0 false false false MicrosoftInternetExplorer4 <![endif]--><!--[if gte mso 9]> <![endif]--> <!-- /* Font Definitions */ @font-face {font-family:Palatino; mso-font-alt:"Book Antiqua"; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:7 0 0 0 147 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; text-align:right; mso-pagination:widow-orphan; direction:rtl; unicode-bidi:embed; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} span.Heading2Char {mso-style-name:"Heading 2 Char"; mso-ansi-font-size:14.0pt; mso-bidi-font-size:14.0pt; font-family:Arial; mso-ascii-font-family:Arial; mso-hansi-font-family:Arial; mso-bidi-font-family:Arial; mso-ansi-language:EN-US; mso-fareast-language:EN-US; mso-bidi-language:AR-SA; font-weight:bold; font-style:italic;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} <![endif]-->