Comparison of the hemodynamic effects of Etomidate versus propofol, Rapid Sequence Intubation, on none surgical patients

Introduction Rapid sequence intubation is planned to protect airway from aspiration and keep patient's ventilation in critically ill cases. Intubation need a sedative drug that has the least hemodynamic instability effect and complications. This prospective-randomized study compared the hemodynamic effects of Etomidate and propofol during Rapid sequence Intubation on non surgical patients. Materials & Methods Critically ill patients with ASA III, IV who needed rapid sequence intubation were divided into two groups of 47 patients. Patients first sedated with 2µ/kg fentanyl and ventilated with bag and mask (sellick's maneouvre). In group 1 1mg/kg propofol and in group 2 0.3 mg/kg etomidate were injected.Vital signs and oxygen saturation were recorded before and five minutes after intubation. Results Demographic data were similar in two groups. Systolic and diastolic blood pressure, heart rate and oxygen saturation were similar in two groups before intubation, but five minutes after intubation hemodynamic changes were less in etomidate group (p=0.000, p=0.000, p=0.047, p=0.004 respectively). Conclusion Usage of etomidate for sedation in rapid sequence intubation had better hemodynamic stability effect than propofol.