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2009•Research Journal of Pharmacy and TechnologyRequires access

RP-HPLC Method for Determination of Aceclofenac, Chlorzoxazone and Paracetamol in Bulk and Pharmaceutical Formulation

Kothapalli Lp, AH Yadav, HI Pawar, VC Dewoolkar, AG Banerjee, Thomas Ab, AD Deshpande

Open publisher page 8 citations

Abstract

A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the simultaneous estimation of aceclofenac (ACE), paracetamol (PARA) and chlorzoxazone (CHZ), in the pharmaceutical formulation using RP-C8 column. The mobile phase (Acetonitrile and Double distilled water) was pumped at a flow rate of 1 ml/min in the ratio of 60:40 and the eluents were monitored at 230.0 nm. Linearity was obtained in the concentration range of 1–60 μg/ml for ACE, 1–50 μg/ml for PARA and CHZ. The accuracy of the method was found to be 98–102% and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining aceclofenac, chlorzoxazone and paracetamol in bulk drug samples or in pharmaceutical dosage form.

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What this paper is about

A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the simultaneous estimation of aceclofenac (ACE), paracetamol (PARA) and chlorzoxazone (CHZ), in the pharmaceutical formulation using RP-C8 column. The mobile phase (Acetonitrile and Double distilled water) was pumped at a flow rate of 1 ml/min in the ratio of 60:40 and the eluents were monitored at 230.0 nm. Linearity was obtained in the concentration range of 1–60 μg/ml for ACE, 1–50 μg/ml for PARA and CHZ. The accuracy of the method was found to be 98–102% and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining aceclofenac, chlorzoxazone and paracetamol in bulk drug samples or in pharmaceutical dosage form.

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Available abstract

A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the simultaneous estimation of aceclofenac (ACE), paracetamol (PARA) and chlorzoxazone (CHZ), in the pharmaceutical formulation using RP-C8 column. The mobile phase (Acetonitrile and Double distilled water) was pumped at a flow rate of 1 ml/min in the ratio of 60:40 and the eluents were monitored at 230.0 nm. Linearity was obtained in the concentration range of 1–60 μg/ml for ACE, 1–50 μg/ml for PARA and CHZ. The accuracy of the method was found to be 98–102% and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining aceclofenac, chlorzoxazone and paracetamol in bulk drug samples or in pharmaceutical dosage form.

Key concepts: Aceclofenac, Chlorzoxazone, Chromatography, High-performance liquid chromatography, Dosage form, Distilled water, Chemistry, Acetonitrile

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