2000•PubMedOpen access

Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits.

Ying-Jie Wang, Meng-Dong Li, Yu‐Ming Wang, Guo-Zheng Chen, Guo-Dong Lu, Zao-Xia Tan

Abstract

AIM:To evaluate the possibility of using cultured human hepatocytes as a bridge between bioartificial liver and liver transplantation.METHODS:In this experiment,the efficacy of extracorporeal bioartificial liver support system (EBLSS) consisting of spheriodal human liver cells and cultured hepatocytes supernatant was assessed in vivo using galactosamine induced rabbit model of fulminant hepatic failure.RESULTS:There was no difference of survival between the two groups of rabbits, but in the supported rabbits serum alanine aminotransferase, total bilirubin and creatinine were significantly lower and hepatocyte necrosis was markedly milder than those in control animals. In addition, a good viability of human liver cells was noted after the experiment.CONCLUSION:EBLSS plays a biologic role in maintaining and compensating the function of the liver.

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Available abstract

Key concepts: Bioartificial liver device, Fulminant hepatic failure, Extracorporeal, Bilirubin, Liver transplantation, Medicine, In vivo, Creatinine