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2007•Advances in Cardiovascular DiseasesRequires access

Tissue Factor and Tissue Factor Pathway Inhibitor in Coronary Atherosclerotic Plaque

Ying Zhu, Xinping Luo, Duan Ma

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Abstract

Tissue factor(TF) is a receptor for factor FVII/FVIIa on a cell surface.It is an important initiator of the exdogenous coagulation cascade,and TF activates exdogenous coagulation cascade and causes thrombosis.Human tissue factor pathway inhibitor(TFPI) is a member of the Kunitz-type serine protease inhibitor family,which is divided into TFPI-1 and TFPI-2.The key function of TFPI-1 is anti-coagulation,while TFPI-2 as a broad-spectrum serine protease inhibitor can function as an MMP inhibitor.The differences between TFPI-1 and TFPI-2 lead to discrepancies in the roles they play in a variety of pathological processes in coronary atherosclerotic plaque.This article reviews recent progress in the related research.

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What this paper is about

Tissue factor(TF) is a receptor for factor FVII/FVIIa on a cell surface.It is an important initiator of the exdogenous coagulation cascade,and TF activates exdogenous coagulation cascade and causes thrombosis.Human tissue factor pathway inhibitor(TFPI) is a member of the Kunitz-type serine protease inhibitor family,which is divided into TFPI-1 and TFPI-2.The key function of TFPI-1 is anti-coagulation,while TFPI-2 as a broad-spectrum serine protease inhibitor can function as an MMP inhibitor.The differences between TFPI-1 and TFPI-2 lead to discrepancies in the roles they play in a variety of pathological processes in coronary atherosclerotic plaque.This article reviews recent progress in the related research.

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Available abstract

Tissue factor(TF) is a receptor for factor FVII/FVIIa on a cell surface.It is an important initiator of the exdogenous coagulation cascade,and TF activates exdogenous coagulation cascade and causes thrombosis.Human tissue factor pathway inhibitor(TFPI) is a member of the Kunitz-type serine protease inhibitor family,which is divided into TFPI-1 and TFPI-2.The key function of TFPI-1 is anti-coagulation,while TFPI-2 as a broad-spectrum serine protease inhibitor can function as an MMP inhibitor.The differences between TFPI-1 and TFPI-2 lead to discrepancies in the roles they play in a variety of pathological processes in coronary atherosclerotic plaque.This article reviews recent progress in the related research.

Key concepts: Tissue factor pathway inhibitor, Tissue factor, Coagulation, Serine protease, Medicine, Thromboplastin, Thrombosis, Coagulation cascade

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