PENETAPAN NILAI PARAMETER LIPOFILISITAS (LOG P, JUMLAH TETAPAN HANSCH DAN TETAPAN f REKKER) ASAM PIPEMIDAT

Lipophilicity is the most often used physicochemical property in quantitative structure-activity relationships (QSAR) studies because it is related to the absorption across biological membrane and the distribution between body fluid and lipid-rich phase of drugs. Its quantitative descriptor is the octanol-water partition coefficient (usually expressed as log P). The 1-octanol-water partition coefficient of pipemidic acid was determined by an experimental using the shake-flask method and by calculating from p Hansch and f Rekker constant. The values of logarithmic intrinsic partition coefficient (IPC) and apparent partition coefficient (APC) of pipemidic acid were -2,03 ± 0,25 and -3,932 ± 0,25. The values of logarithmic partition coefficient, which were obtained by calculating of p Hansch and f Rekker constant were -1,65 and -1,981, respectively.