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Relationship among PS2 protein expression, estrogen and progesterone receptor status, and prognosis of breast cancer

Jingxian Liu, Jiyou Li, He Luowen, Zhao Yajuan

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Abstract

Objective: To study the relationship between the expression of PS 2 protein and Estrogen (ER) and Progesterone Receptor (PR) status and their prognotic value in breast cancer. Methods: Using the immunohistochemical method, PS 2 protein expressions were detected in 105 cases with breast cancer. Results: The positive rate of PS 2 protein was 50.48% (53/105) in 105 cases. The positive rate of PS 2 in the patients who survived five years or more was 56.96% (45/79), which was higher than that of those who lived less than five years (30.77%, 8/26). In the ER, PR (+) patients, the positive rate of PS 2 was higher (76.74%, 33/34), than that of those with ER, PR (−) (22.5%, 9/40). Conclusions: Our results suggest that the expression of PS 2 protein was positively correlated with the 5-year-survival and that of ER and PR in breast cancer. It is considered that PS 2 may be as a prognostic predictor, and detection of PS 2 protein expression was useful for a guiding treatment of breast cancer.

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Objective: To study the relationship between the expression of PS 2 protein and Estrogen (ER) and Progesterone Receptor (PR) status and their prognotic value in breast cancer. Methods: Using the immunohistochemical method, PS 2 protein expressions were detected in 105 cases with breast cancer. Results: The positive rate of PS 2 protein was 50.48% (53/105) in 105 cases. The positive rate of PS 2 in the patients who survived five years or more was 56.96% (45/79), which was higher than that of those who lived less than five years (30.77%, 8/26). In the ER, PR (+) patients, the positive rate of PS 2 was higher (76.74%, 33/34), than that of those with ER, PR (−) (22.5%, 9/40). Conclusions: Our results suggest that the expression of PS 2 protein was positively correlated with the 5-year-survival and that of ER and PR in breast cancer. It is considered that PS 2 may be as a prognostic predictor, and detection of PS 2 protein expression was useful for a guiding treatment of breast cancer.

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Available abstract

Objective: To study the relationship between the expression of PS 2 protein and Estrogen (ER) and Progesterone Receptor (PR) status and their prognotic value in breast cancer. Methods: Using the immunohistochemical method, PS 2 protein expressions were detected in 105 cases with breast cancer. Results: The positive rate of PS 2 protein was 50.48% (53/105) in 105 cases. The positive rate of PS 2 in the patients who survived five years or more was 56.96% (45/79), which was higher than that of those who lived less than five years (30.77%, 8/26). In the ER, PR (+) patients, the positive rate of PS 2 was higher (76.74%, 33/34), than that of those with ER, PR (−) (22.5%, 9/40). Conclusions: Our results suggest that the expression of PS 2 protein was positively correlated with the 5-year-survival and that of ER and PR in breast cancer. It is considered that PS 2 may be as a prognostic predictor, and detection of PS 2 protein expression was useful for a guiding treatment of breast cancer.

Key concepts: Breast cancer, Progesterone receptor, Immunohistochemistry, Estrogen receptor, Medicine, Internal medicine, Estrogen, Protein expression

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