1969•JNCI Journal of the National Cancer InstituteRequires access

Induction of Intestinal and Urinary Bladder Cancer in Rats by Feeding Bracken Fern (Pteris aquilina) 1

A. M. Pamukcu, James M. Price

Abstract

Simultaneous intestinal and urinary bladder tumors were induced in rats by feeding them bracken fern (Pteris aquilina). Adenomatous polyps and adenocarcinomas developed predominantly in the ileum. These neoplasms were homogeneous and were sharply demarcated from adjacent normal mucosa. Urinary bladder tumors consisted of papillomas and carcinomas, and a high degree of malignancy followed the bracken feeding.

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Key concepts: Bracken, Fern, Medicine, Urinary bladder, Malignancy, Urinary system, Pathology, Anatomy