Percutaneous absorption of radioactive strontium chloride Sr 89 (89SrCl2). A comparison with 11 other metal compounds

By means of an in vivo isotope technique, the so-called disappearance measurements, the percutaneous absorption of strontium chloride in six different concentrations (0.00013 to 0.753 M) was studied in the guinea pig. It was found that the relative absorption was about the same (2.5% to 3.1% during a five-hour period) in the concentration interval 0.008 to 0.398 M, with the maximum at 0.080 M. The absolute absorption increased with increasing concentration. A summary comparison showed that the absorption of strontium chloride was of the same order of magnitude as that observed for metal compounds previously studied. The rapid absorption of strontium compounds reported in the literature could not be verified.