Ligand-Binding Assays for Collagen

Collagen is one of the most physiologically important agonists for platelet function. Two collagen-specific receptors, integrin α 2 β 1 and glycoprotein (GP) VI, have been identified on the platelet surface from studying patient’s platelets deficient in one of these proteins ( 1 , 2 ). Integrin α 2 β 1 was found to be the major receptor responsible for platelet adhesion to collagen ( 3 , 4 ). The other collagen receptor, GPVI, was indicated to contribute to platelet activation and aggregation by its involvement in collagen-induced signaling pathways ( 5 , 6 ). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.