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2004•Unpublished venueRequires access

MRI of the Spinal Cord in Vitamin B12 Deficiency

Chin-Hua Fu, Hui-Ching Chen, Wen‐Long Tsao

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Abstract

Vitamin B12 deficiency causes hematological and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord characterized by degeneration of the lateral and posterior columns is often found due to vitamin B12 deficiency. We described three patients with SCD presenting with cervical and thoracic myelopathy. Laboratory data revealed vitamin B12 deficiency and MRI of the spinal cord demonstrated abnormal hyperintense signal changes on T2-weighted imaging involving the posterior and lateral columns. Early recognition of this specific MRI pattern is essential in these patients even before the results of laboratory tests are available to ensure early and prompt treatment at the reversible stage. In our cases, follow-up MRI findings correlated well with clinical outcome after treatment with Vitamin B12 supplements. (Tzu Chi Med J 2004; 16:199-204)

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What this paper is about

Vitamin B12 deficiency causes hematological and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord characterized by degeneration of the lateral and posterior columns is often found due to vitamin B12 deficiency. We described three patients with SCD presenting with cervical and thoracic myelopathy. Laboratory data revealed vitamin B12 deficiency and MRI of the spinal cord demonstrated abnormal hyperintense signal changes on T2-weighted imaging involving the posterior and lateral columns. Early recognition of this specific MRI pattern is essential in these patients even before the results of laboratory tests are available to ensure early and prompt treatment at the reversible stage. In our cases, follow-up MRI findings correlated well with clinical outcome after treatment with Vitamin B12 supplements. (Tzu Chi Med J 2004; 16:199-204)

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Available abstract

Vitamin B12 deficiency causes hematological and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord characterized by degeneration of the lateral and posterior columns is often found due to vitamin B12 deficiency. We described three patients with SCD presenting with cervical and thoracic myelopathy. Laboratory data revealed vitamin B12 deficiency and MRI of the spinal cord demonstrated abnormal hyperintense signal changes on T2-weighted imaging involving the posterior and lateral columns. Early recognition of this specific MRI pattern is essential in these patients even before the results of laboratory tests are available to ensure early and prompt treatment at the reversible stage. In our cases, follow-up MRI findings correlated well with clinical outcome after treatment with Vitamin B12 supplements. (Tzu Chi Med J 2004; 16:199-204)

Key concepts: Subacute Combined Degeneration, Vitamin B12, Medicine, Spinal cord, Myelopathy, Spinal Cord Diseases, Magnetic resonance imaging, Cord

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