1974•PubMedRequires access
Immunogenicity of lowly and highly derivatized dinitrophenyl-bovine gamma-globulin in different strains of guinea pigs.
Luis Quijada, Young Tae Kim, Gregory W. Siskind, Z Ovary
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Abstract
Guinea pigs immunized with lowly derivatized dinitrophenylated bovine gamma globulin produced large amounts of antibody directed against the carrier molecule and large amounts of antibody directed against the hapten. Guinea pigs immunized with a highly derivatized preparation did not produce antibody against the carrier but produced large amounts of antibody directed against the hapten. Both preparations provoked the production of about the same amount of anti-hapten antibody, but the lowly derivatized antigen provoked the production of anti-hapten antibody of higher average affinity.