Effect of hypertonic saline solution infusion on haemodynamics of endotoxemic buffalo calves

Apparently healthy male buffalo calves (10) were subjected to endotoxic shock by i/v infusion of E. coli endotoxin @ 5 µg/kg BW/hr for 3 hr. Out of these 1 group'of 5 calves was left untreated and observed for next 4 hr while the other group of S calves were given rapid i/v infusion'of hypertonic saline solution (7.2% NaCI) @4 ml/kg BW in 6.5 min. The endotoxin infusion caused a significant decline in systolic, diastolic, pulse pressure. mean arterial pressure (MAP) and central venous pressure (CVP) in both. groups during endotoxin infusion. In hypertonic saline treated group. following infusion. all these parameters showed vast improvement while in untreated group, these values were significantly lower than normal till end of observation period. Mean body temperature varied only nonsignificantly while respiratory rate was markedly elevated in both groups. during and after infusion of endotoxin. The various beneficial effecrs of hypertonic saline on haemodynamics were transient in nature and had no effect on body temperature and respiration.