Hypofibrinogenemia in Abruptio Placenta

As early as 1901, DeLee described a hemophilic-like condition of the blood in abruptio. Dieckmann in 1936, studying a group of patients with abruptio, found fibrinogen concentration below the normal levels in seven out of eleven cases, and in three where the fibrinogen level was below 50 mg./100 c.c. During the past few years hypofibrinogenemia has been shown to exist in other conditions apart from abruptio, such as, fetal death in utero due to isosentization to Rh, and fetal retention, amniotic fluid embolus, severe eclampsia, abortion and retained placenta.