Anti-Glomerular Basement Membrane Disease Associated with Membranous Nephropathy: A Case Report and Literature Review

Anti-glomerular basement membrane (GBM) disease associated with membranous nephropathy (MN) is rare. We reported a 66-year-old woman with hematuria, proteinuria, hemoptysis, fever, and acute renal failure. The serum titer of anti-GBM autoantibody was 1:160. The renal biopsy showed cellular crescent, diffuse thickening of glomerular basement membrane, and a granular but not linear pattern of immunofluorescence along the glomerular capillary wall. Corticosteroid and mycophenolate mofetil (MMF) were tried, but she died of sepsis. Review of the literature suggests that the outcome of patients with combined anti-GBM disease and MN was poor, especially if poor prognostic factors existed.