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Effect of human neural progenitor cells on injured spinal cord.

徐光辉, 白金柱, Qin-Lin Cai, 李肖霞, 李凌松, 沈丽

Abstract

OBJECTIVE: To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats. METHODS: Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry. RESULTS: Human neural progenitor cells developed into functional cells in the injured spinal cord and improved the recovery of injured spinal cord in both locomotor scores and electrophysiological parameters in rats. CONCLUSIONS: Human neural progenitor cells can treat injured spinal cord, which may provide a new cell source for research of clinical application.

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Key concepts: Spinal cord, Progenitor cell, Neural stem cell, Progenitor, Spinal cord injury, Medicine, Neuroscience, Anatomy