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Chitosan/Poly -Glutamic acid의 EDC/NHS 가교를 통한 pH-감응성 hydrogel의 제조 및 약물전달지지체로서의 응용

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Abstract

pH-sensitive hydrogels composed of Chitosan and Poly(γ-Glutamic acid) (γ-PGA) were prepared by the freeze drying method and EDC/NHS cross-linked to suppress the deformation of hydrogel in water. The physical properties, swelling and drug diffusion behaviors were characterized for the hydrogels. In equilibrium swelling study, Chitosan/γ-PGA hydrogels shrunk in pH resions below pKa(2.27) of γ-PGA whereas they swelled above pKa. In the drug diffusion study, the drug permeation rates of Chitosan/γ-PGA hydrogels were directly proportional to their swelling behaviors. The cytocompatibility test showed no cytotoxicity of Chitosan/γ-PGA hydrogels for the NIH 3T3 cell lines. The results of above studies suggest that the hydrogels prepared from Chitosan and γ-PGA can be utilized as an orally administrable drug delivery system.

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What this paper is about

pH-sensitive hydrogels composed of Chitosan and Poly(γ-Glutamic acid) (γ-PGA) were prepared by the freeze drying method and EDC/NHS cross-linked to suppress the deformation of hydrogel in water. The physical properties, swelling and drug diffusion behaviors were characterized for the hydrogels. In equilibrium swelling study, Chitosan/γ-PGA hydrogels shrunk in pH resions below pKa(2.27) of γ-PGA whereas they swelled above pKa. In the drug diffusion study, the drug permeation rates of Chitosan/γ-PGA hydrogels were directly proportional to their swelling behaviors. The cytocompatibility test showed no cytotoxicity of Chitosan/γ-PGA hydrogels for the NIH 3T3 cell lines. The results of above studies suggest that the hydrogels prepared from Chitosan and γ-PGA can be utilized as an orally administrable drug delivery system.

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Available abstract

pH-sensitive hydrogels composed of Chitosan and Poly(γ-Glutamic acid) (γ-PGA) were prepared by the freeze drying method and EDC/NHS cross-linked to suppress the deformation of hydrogel in water. The physical properties, swelling and drug diffusion behaviors were characterized for the hydrogels. In equilibrium swelling study, Chitosan/γ-PGA hydrogels shrunk in pH resions below pKa(2.27) of γ-PGA whereas they swelled above pKa. In the drug diffusion study, the drug permeation rates of Chitosan/γ-PGA hydrogels were directly proportional to their swelling behaviors. The cytocompatibility test showed no cytotoxicity of Chitosan/γ-PGA hydrogels for the NIH 3T3 cell lines. The results of above studies suggest that the hydrogels prepared from Chitosan and γ-PGA can be utilized as an orally administrable drug delivery system.

Key concepts: Self-healing hydrogels, Chitosan, Swelling, Chemistry, Drug delivery, Permeation, Drug carrier, Diffusion

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Chitosan/Poly -Glutamic acid의 EDC/NHS 가교를 통한 pH-감응성 hydrogel의 제조 및 약물전달지지체로서의 응용 — Research Paper | ScholarLens