2011•Research Journal of Pharmacology and PharmacodynamicsRequires access

Hepatoprotective Effect of Pergularia daemia on Cadmium Chloride Induced Toxicity in Rats

Padma Kumar, Ch. Sudheer Kumar, V. Veera Thamarai Selvi, A.Amala bricey

Abstract

The present study was undertaken to examine the inhibitory effect of the Pergularia daemia on cadmium chloride induced hepatoprotective activity in liver. In rats injected with cadmium chloride, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), γ -glutamyl transferase (GGT) was significantly (p < 0.05) increased when compared to those values in control rats. The rats administrated with P.daemia extract and cadmium chloride showed a significantly (p < 0.05) decreased levels of serum AST, ALP, LDH and GGT. This study suggested that P.daemia may be implicated as a hepatoprotective agent for therapeutic purposes.

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Key concepts: Cadmium chloride, Lactate dehydrogenase, Alanine aminotransferase, Cadmium, Toxicity, Pharmacology, Chemistry, Traditional medicine