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2004•Indian Journal of Animal ResearchRequires access

Pathomorphological changes in rats following infection with Trypanosoma evansi isolated from a heterologous host

Nitin Virmani, Pinaki Prasad Sengupta, A. S. Panisup

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Abstract

Albino rats infected experimentally with Trypanosoma evansi (isolated from camel) revealed parasitaemia by day 2 post infection. The infected animals became dull and depressed and showed abnormal movements from 2 DPI onwards. Postmortem examination revealed splenomegaly, marked congestion of lungs, petechiae on serous surfaces and the entire surface of liver along with presence of fluid in peritoneal and pericardial cavities from 4–6 DPI (the maximum period of observation). Histopathologically, heart muscles showed hyaline degenerative changes and haemorrhages. Liver parenchyma revealed congestion of central vein and sinusoids. Haemosiderosis was found in liver, spleen, heart and lungs. Renal tubules had some hyaline cast. The organisms could be demonstrated in sections of liver and kidney only.

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What this paper is about

Albino rats infected experimentally with Trypanosoma evansi (isolated from camel) revealed parasitaemia by day 2 post infection. The infected animals became dull and depressed and showed abnormal movements from 2 DPI onwards. Postmortem examination revealed splenomegaly, marked congestion of lungs, petechiae on serous surfaces and the entire surface of liver along with presence of fluid in peritoneal and pericardial cavities from 4–6 DPI (the maximum period of observation). Histopathologically, heart muscles showed hyaline degenerative changes and haemorrhages. Liver parenchyma revealed congestion of central vein and sinusoids. Haemosiderosis was found in liver, spleen, heart and lungs. Renal tubules had some hyaline cast. The organisms could be demonstrated in sections of liver and kidney only.

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Available abstract

Albino rats infected experimentally with Trypanosoma evansi (isolated from camel) revealed parasitaemia by day 2 post infection. The infected animals became dull and depressed and showed abnormal movements from 2 DPI onwards. Postmortem examination revealed splenomegaly, marked congestion of lungs, petechiae on serous surfaces and the entire surface of liver along with presence of fluid in peritoneal and pericardial cavities from 4–6 DPI (the maximum period of observation). Histopathologically, heart muscles showed hyaline degenerative changes and haemorrhages. Liver parenchyma revealed congestion of central vein and sinusoids. Haemosiderosis was found in liver, spleen, heart and lungs. Renal tubules had some hyaline cast. The organisms could be demonstrated in sections of liver and kidney only.

Key concepts: Trypanosoma evansi, Hyaline, Spleen, Parenchyma, Pathology, Heterologous, Kidney, Biology

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Pathomorphological changes in rats following infection with Trypanosoma evansi isolated from a heterologous host — Research Paper | ScholarLens