건선 환자에서 involucrin , loricrin , filaggrin , bcl-2 의 발현에 관한 면역조직화학적 연구

Background : The pathogenesis of psoriases remains upcertain. It is konwn that a variety of factors take a role in its pathogencsis. One of them is the lteration of keratimocytes differentiation. The terminal differentiation of kerationocyles includes the process of the synthesis of proteins such as involucrin, filaggrin and cornifin, and produce keratohyaline granules and a structure terned cornified cell envelope finally. And the terninal differentiation of keratinocytes is konwn as a process of apoptosis, proguamned cell death . Objective : In this study, we tried to clarify the pathogenctic mechanisms of psoriasis by comparing the expression patterns of several proteins(involuerin, loricrin, filaggrin) associated with keratinocyte differentiation and of bel-2 protein, known as inhibitor of apoprosis, between lesional and non-lesional psoriatic skin. Results : The results were summarized as follows, firstly early expression of involuerin in lower epidermis, secondly on or reduced expression of filaggrin and lorierin in upper epidermis and lastly no expression of bel-2 in basal layer of psoriatic skin. Conclusion : This study clarified that the accelerated terminal differentiation, the shortening of cell-cycle of keratinocyles, and the increased trunover of gerationcytes may be involved in the pathogenetic role of psoriasis.