2016•Current Eye ResearchRequires access

Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate

Patricia Loma, Ana Guzmán‐Aránguez, María J. Pérez de Lara, Jesús Pintor

Abstract

PURPOSE: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. METHODS: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA). RESULTS: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists. CONCLUSIONS: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation.

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Key concepts: Lactoferrin, Tears, Receptor, Chemistry, Secretion, Pipette, Pharmacology, Endocrinology