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The HPV Vaccine and Cervical Neoplasia: Not Just for Warts Anymore

Craig A. Elmets

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Abstract

Genital infection with human papillomavirus (HPV) is the etiologic agent for almost all cervical cancers; approximately 70% of cases involve HPV type 16 or 18. High-grade cervical lesions often begin to develop within 2 years of HPV infection. To determine whether a quadrivalent HPV vaccine (Gardasil) could prevent cervical intraepithelial neoplasia (CIN), investigators conducted a phase 3 trial in more than 10,000 women (age …

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What this paper is about

Genital infection with human papillomavirus (HPV) is the etiologic agent for almost all cervical cancers; approximately 70% of cases involve HPV type 16 or 18. High-grade cervical lesions often begin to develop within 2 years of HPV infection. To determine whether a quadrivalent HPV vaccine (Gardasil) could prevent cervical intraepithelial neoplasia (CIN), investigators conducted a phase 3 trial in more than 10,000 women (age …

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Available abstract

Genital infection with human papillomavirus (HPV) is the etiologic agent for almost all cervical cancers; approximately 70% of cases involve HPV type 16 or 18. High-grade cervical lesions often begin to develop within 2 years of HPV infection. To determine whether a quadrivalent HPV vaccine (Gardasil) could prevent cervical intraepithelial neoplasia (CIN), investigators conducted a phase 3 trial in more than 10,000 women (age …

Key concepts: Medicine, Gardasil, Genital warts, Cervical intraepithelial neoplasia, Cervical cancer, Human papillomavirus, HPV infection, HPV vaccines

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